8/9/2023 0 Comments Uutz wordpresscomThe development of ultra-sensitive detectors and amplifiers is therefore an important part of our work.Īnother, maybe less obvious difficulty lies in the control of the magnetic field itself. This leads to correspondingly weak signals, which are difficult to pick up. Some of the difficulties are associated with the small sample volumes that are typically used in microfluidic systems. This is the main objective and field of activity of our research group. Microfluidic NMR spectroscopy faces a range of technical and spectroscopic problems which must be overcome in order to make the approach useful in practice. It is the source of a large part of our current knowledge on the structure and dynamics of matter at the molecular scale. It is therefore no wonder that NMR spectroscopy has found widespread applications in chemistry, physics, biology, medicine, and materials science. Integration of NMR spectroscopy into such a system would enable us to follow the metabolism of these cells in vivo and in real time without perturbing or destroying them. This allows us to cultivate highly specialised cell types, for example liver cells, which are difficult to grow in bulk cultures. For example, microfluidic devices can provide cells with a controlled growth environment that mimics natural tissue. These are micro fabricated systems, not unlike electronic microdevices, which integrate a complex chemical or biological experiment in a small, usually expendable platform. While the most common NMR instruments work with samples ranging from a few cm to a couple meters in size (think of clinical magnetic resonance imaging scanners!), it is an obvious idea to try and combine NMR spectroscopy with modern miniaturised lab-on-a-chip devices. Therefore, the nuclei come close to being ideal spies: they experience and report everything that goes on around them, without being “seen”. Conversely, the spin precession of the nuclei has a negligible effect on the electronic structure.Ĭombining NMR with microfluidic Lab-On-A-Chip devices would have obvious benefits, but presents significant challenges These differences are small,but can readily be measured with high-quality instruments. The precession frequency of each nucleus is poportional to the magnetic field, but it is also affected somewhat by the details of the electron structure that surrounds the nucleus. It relies on the precession of the magnetic moments associated with atomic nuclei in a string magnetic field. Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful and versatile tools in the hand of the chemist, biologist, and materials engineer.
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